Fuel, time & distance
Groundspeed determines how long a leg takes. Fuel flow determines consumption over that time. Fuel for starting, taxiing, climbing, alternates, delays, and reserves can change the total substantially. Usable fuel is not necessarily the same as tank capacity.
Wind & navigation
Heading is where the nose points; track is the path over the ground. Crosswind creates drift, while the along-track wind changes groundspeed. A wind triangle connects these quantities. Mixing true and magnetic directions can make an otherwise correct calculation wrong.
Altitude & aircraft performance
Hotter, less dense air affects lift, engine power, and propeller performance. Density altitude puts that air density on a standard-atmosphere altitude scale. It is not a substitute for the aircraft's takeoff, landing, and climb charts.